Ramanisblog

Tag: hormones

  • The Dangers of Hormone Therapy: Why Is It Still Prescribed?


    Martha Rosenberg and Rowan Chlebowski, a lead investigator of the Women’s Health Initiative, talk about why doctors still promote hormone therapy despite its health risks.|

    In the following interview Martha Rosenberg and Rowan Chlebowski, MD, a lead investigator of the Women’s Health Initiative, talk about why doctors still promote hormone therapy despite its cancer, heart disease, stroke and blood clot risks.

    Martha Rosenberg: The Women’s Heath Initiative findings about hormone therapy (HT) were definitive enough that both the estrogen and estrogen plus progestin arms of the study were terminated. Yet claims of heart and memory benefits for women, if HT is started early enough, continue in the media. Is there new information that has changed the risk/benefit ratio?

    Rowan Chlebowski: The new information was a secondary analysis of WHI data which ran in JAMA in 2007 and found HT may not be as detrimental for coronary heart disease as previously thought, if started in early menopause. Risk for stroke did not change, however, and there are indications that breast cancers appeared earlier, when hormones were started earlier.

    M.R.: Why are some doctors and Continuing Medication Education courses presenting HT as cardioprotective?

    R.C.: That claim is heard more from the gynecological community which had been the biggest HT prescribers rather than from the general medicine or the oncology community. The FDA has not changed the prescribing label on the basis of the WHI secondary analysis. HT is still not a desirable chronic disease risk reduction agent though for short term relief of vasomotor systems like hot flashes no other therapy comes close.

    M.R.: Do you believe the “timing theory”–that HT has greater benefits than WHI revealed because women began therapy too late–will be found to have merit?

    R.C.: Of course, the timing theory is just a theory. It would require a very expensive study to investigate. So far, on the basis of secondary analysis from WHI at seven years, the National Institutes of Health has not indicated an interest in a new study about timing.

    M.R.: What about memory and cognition benefits and the claim that HT could prevent dementia?

    R.C.: The Women’s Health Initiative Memory Study which was a substudy of women 65 or older found, after four years of HT, all types of dementia doubled in women. Some of these findings could be related to the increase in stroke that was seen in this group.

    M.R.: Why do doctors still promote HT despite its cancer, heart disease, stroke and blood clot risks? Are they influenced by drug companies?

    R.C.: Certainly the estrogen drug used in the trials, Premarin, and the estrogen plus progestin drug Prempro are best selling products of Pfizer, previously Wyeth. These companies are also big supporters of the gynecology community. It is reasonable for companies to support groups who use their products so it becomes a chicken and the egg question. The gynecology community tends to focus more on heart problems than the data about breast or lung cancer that is increasingly emerging from WHI.

    M.R.: Why is WHI billed as a landmark study? Haven’t a lot of studies looked at these issues like the PEPI, HERS, the Million Women Study and the Nurses’ Health studies?

    R.C.: The PEPI study[Postmenopausal Estrogen/Progestin Interventions Trial] largely investigated estrogen’s effect on the uterus and led to WHI’s addition of a progestin to estrogen to prevent endometrial cancers. The HERS study[Hormone Therapy Estrogen Cardiovascular Protection Clinical Trials] looked at women with established coronary heat disease and found no beneficial effect of HT looking at cardiovascular end-points. The Million Women Study in the UK is an observational study and the Nurses’ Health Study also is an observational study at Harvard of younger women. The WHI trial is the only fully powered randomized, placebo controlled trial able to address the most frequent causes of death and disability in postmenopausal women–cardiovascular disease, cancer, and osteoporosis.
    http://www.alternet.org/story/145944/the_dangers_of_hormone_therapy%3A_why_is_it_still_prescribed

  • ‘Testosterone’s aggressive impact is a myth. It makes you friendlier’

    Male species have the inbuilt tendency to protect its own.In that process , if it considers the action of the other gender will endanger it and thence the male species,the male species shall compel the other species to behave the way it should behave to avoid risk to the female.Indian Philosophy states that a woman should be and under the care of parents when in child hood,of husband in womanhood and of children in old age;under no circumstances, are they to be left alone to fend for themselves.
    Under the following circumstances, one can kill;those who sets fire to homes, who poisons,who takes away one’s belongings and who threatens wife and children.
    This is nature.may be Hormones have some thing to do with it.
    If feminists believe this male chauvinism, be it.You can not challenge Nature.
    t is popularly known as the selfish hormone, which courses through male veins to promote egotistical and antisocial behaviour. Yet research has suggested that testosterone’s bad reputation is largely undeserved.

    Far from always increasing aggression and greed, the male hormone can actually encourage decency and fair play, scientists have discovered.

    The common belief that it makes people quarrelsome, however, can cause it to have that effect. When people think they have been given supplements of the hormone they tend to act more aggressively, even though it does nothing biological to promote such behaviour.

    The findings, from an Anglo-Swiss team, suggest that rather than encouraging selfishness and risk-taking as a matter of course, testosterone has subtler effects on human behaviour that depend very much on social circumstances.
    http://www.timesonline.co.uk/tol/news/uk/health/article6949048.ece