Cancer, The Facts

Facts worth knowing.
Story:
One in three of us will be diagnosed with cancer during our life.

The disease tends to affect older people – but can strike at any time.

Excluding certain skin cancers, there were almost 290,000 new cases of the disease in 2005.

Some cancer, such as breast, are becoming more common, while new cases of lung cancer are expected to fall away due to the drop in the number of smokers.

However, while the overall number of new cancers is not falling, the good news is that successful treatment rates for many of the most common types are improving rapidly.

Latest Study:

Latest Figures indicate that the incidence of Cancer is declining marginally.

However, the incidence of Cancer is also rising.

The overall trends in declining cancer death rates continue. However, increases in incidence rates for some HPV-associated cancers and low vaccination coverage among adolescents underscore the need for additional prevention efforts for HPV-associated cancers, including efforts to increase vaccination coverage.

The initial report documented the first steady decline in cancer death rates, beginning in the early 1990s, since national record keeping on vital statistics began in 1930 (1). In addition to providing updates on incidence and mortality patterns, each report features a topic of special interest (2–14). This report features the burden and trends in human papillomavirus (HPV)–associated cancers among persons aged 15 years or older and HPV vaccination coverage levels among adolescents aged 13 to 17 years.

Exposure to HPV is common through sexual contact, and most infections resolve over time. However, persistent infection with oncogenic HPV types is etiologically linked to cervical cancer (15), as well as cancers of the oropharynx (16), anus (17), vagina and vulva (18), and penis (19,20). Virtually all cervical cancers are due to HPV infection, along with 90% of anal cancers, more than 60% of certain subsites of oropharyngeal cancers, and 40% of vagina, vulva, and penile cancers (20). Although there are approximately a dozen oncogenic HPV types, HPV 16 and 18 are the most common HPV types and are found in approximately 70% of cervical cancers. Human papillomavirus 16 is found in approximately 90% of the noncervical cancers often associated with HPV infection (20). Human papillomavirus types 6 and 11 are associated with the development of 90% of anogenital warts (21). Two vaccines (bivalent and quadrivalent) are available to protect against HPV types 16 and 18. Data from clinical trials have shown that both vaccines prevent vaccine type–related cervical precancers (22,23); the quadrivalent vaccine has been shown to also prevent vaginal, vulvar, and anal precancers (24,25). Although data show the vaccines prevent various outcomes, no data are available on the efficacy for prevention of HPV-associated cancers or lesions of the oropharynx. Because HPV 16 is responsible for the majority of HPV-associated cancers (20), the vaccines likely protect against these outcomes. The quadrivalent vaccine also protects against HPV 6 and 11, and clinical trials show the vaccine prevents vaccine type–related genital warts (26). The Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination of girls aged 11 or 12 years with three doses of either vaccine and routine vaccination of boys aged 11 or 12 years with three doses of quadrivalent vaccine (27–29). Vaccination is also recommended for women aged 13 through 26 years and men aged 13 through 21 years who were not vaccinated previously. Men aged 22 through 26 years may also receive the vaccine. The goals of the current vaccination recommendations for adolescents are to prevent persistent HPV infections and the occurrence of anogenital warts beginning in young adulthood and cervical, vaginal, vulvar, and anal cancers that occur later in life. The occurrence of cervical cancer can also be prevented through screening (eg, Papanicolaou [Pap] and HPV testing) (30–32), and Pap testing has contributed to the substantial declines in cervical cancer rates in the United States and other developed countries over the past several decades (33).

For detailed report Link below.

http://jnci.oxfordjournals.org/content/early/2013/01/03/jnci.djs491.full?sid=ccafd244-6199-4658-b24d-f139a96187c5

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