However there are signs that show up which might indicate Cancer,
These symptoms need not indicate the presence of cancer,; they might indicate some other Disese as well.
Please remember, the conclusion that the symptoms and tests are arrived at by the reverse Logic, which is not admissible strictly in Logic and Reasoning.
That is it is not that these indicators and the results are the causes of Cancer.
More than 99 per cent of cases of cervical cancer are caused by the human papillomavirus Photo: ALAMY.Image Credit. Telegraph.co UK.
Most of the Cancer patients, at least those who have been surveyed, have all or some of these symptoms .
Some may not have these symptoms at all and some symtoms not known to us may be present.
That’s all.
Then why take these Tests and these symptoms seriously?
These are in the nature of abundant precaution.
That is very important.
The Doctors/Oncologists , with their experience can detect if it is indicative of malignancy and treat you accordingly.
Sad that some use this to make money by instilling fear in the patient.
Now to the Tests for early detection.
Again I emphasize two facts.
1.The parameters of the Test are not uniform.
They vary.
For example , the parameters for Alkaline Phosphate Level varies from Lab to Lab.
”
The normal range is 44 to 147 IU/L (international units per liter).
Normal values may vary slightly from laboratory to laboratory. They also can vary with age and gender. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women.
The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.
Labs parameters say 44-120!”
So when one gets a reading at 149 he is scared.
Under these circumstances it is best to consult a Liver specialist and an Oncologist and have second opinions on both.
2.The results in the Tests may be due to some other normal activity or the side effect of a prescribed Drug intake.
In the case of Alkaline Phosphate, the elevated reading might be due to the intake some medicines or due to excessive Exercise which increases the Alkaline Phosphate Level.
So do not jump to conclusions and take the advice of Doctors and get a second opinion before drugging yourself.
For the benefit of laymen like me, I am posting some tests needed to detect cancer.
Remember I am no Doctor or a specialist; the post is to familiarities the Patient and those close to him so that they do not become unduly worried or to prevent some nonprofessionals from milking you.
”
A complete blood count (CBC) is a common blood test that is used to help diagnose some blood cancers, such as leukemia and lymphoma, tell if a cancer has spread to the bone marrow, and help determine how your body is tolerating cancer treatments. If you are being treated with chemotherapy, your doctor will likely monitor your blood cell counts regularly using CBCs.
A CBC provides important information about the amount of three types of cells in your blood: white blood cells, red blood cells, and platelets. Each of these measurements has a normal range that will be noted on your CBC. Typical test values are given as a range (called a reference range) instead of a specific number because they vary from person to person.
White blood cell (WBC) count. A white blood cell count, also called a leukocyte count, measures the number of WBCs in a sample of blood. WBCs protect the body from infection by attacking invading bacteria, viruses, and other foreign materials in the body. Some WBCs can also attack cancer cells. A normal range for a WBC count is 3,300 to 8,700 WBCs per microliter (mcL).
White blood cell (WBC) differential. A WBC differential is a test that measures the number of each type of WBC. There are five major types of WBCs: neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Each type of cell plays a different role in protecting the body and helping you stay healthy. People with some types of cancer may have higher-than-normal numbers of lymphocytes or monocytes.
Some cancer treatments, especially chemotherapy, may cause a decrease in your body’s WBCs. Cancers that affect the blood and bone marrow, such as leukemia, lymphoma, or multiple myeloma, can cause a decrease in the WBC count. These cancers and cancer treatments may cause a condition called neutropenia, an abnormally low level of neutrophils. Neutrophils are measured by a number called the absolute neutrophil count (ANC). A normal ANC range is 2,500 to 6,000 neutrophils.
A noticeable decrease in the number of neutrophils increases the chances of developing a bacterial infection. At times, your doctor may choose to lower the dose of chemotherapy you receive to decrease your chance of developing low neutrophil counts. Your doctor may also recommend medication, such as white blood cell growth factors, to increase your body’s production of neutrophils, especially if you develop a fever. Learn more about ASCO’s recommendations for white blood cell growth factors.
Red blood cell (RBC) count.RBCs carry oxygen throughout your body, and the number of RBCs can be described in a few different ways. An RBC count, also called an erythrocyte count, measures the number of RBCs in a sample of blood. A normal range for an RBC count is approximately 4 to 6 million RBCs per mcL. The hematocrit is the percentage of your blood that is made up of RBCs. A normal hematocrit range is 38% to 48%. The hemoglobin (HgB) level measures the amount of the protein in RBCs that actually carries the oxygen. If the level of hemoglobin is low, your body works much harder to deliver oxygen to tissues throughout the body. A normal HgB range is 12.6 to 16.1 grams per deciliter.
Some cancer treatments, especially chemotherapy and radiation therapy, may cause a decrease in your body’s RBCs. This condition is known as anemia. Blood loss, either from surgery or from specific cancers, can also cause or worsen anemia. Cancers that directly involve the bone marrow, such as leukemia, lymphoma, or multiple myeloma, can also interfere with the production of RBCs and cause anemia. People whose RBC count falls too low may need a blood transfusion or medication to help increase the body’s RBCs.
Platelet count. A platelet count measures the number of platelets in a sample of blood. Platelets help to stop bleeding by forming blood clots. A normal range for a platelet count is approximately 150,000 to 350,000 platelets per mcL.
Some cancer treatments, such as chemotherapy or radiation therapy, may cause a decrease in platelets, which may result in a condition called thrombocytopenia. Cancers that involve the bone marrow directly, such as leukemia, lymphoma, or multiple myeloma, can also cause a decrease in the production of platelets. Patients with low platelet levels have a greater risk of serious bleeding or bruising. If your platelet count falls to very low levels, your doctor may give you platelet transfusions.
What the results mean
Blood test results must be interpreted carefully by your doctor and other members of your health care team. Keep in mind that many factors, including noncancerous conditions, can lead to results that fall out of the reference range. In addition, neutrophil and platelet counts have to fall to very low levels before infections and bleeding become major risks. Ask your doctor to help you be”
The links below are useful for Procedures and Tests.
English: An ovarian cancer as seen on CT (Photo credit: Wikipedia)
There is so much of information of cancer and symptoms of Cancer, which confuses one.
I have come across a concise information in Web MD.
These symptoms do not necessarily mean one has cancer.
It is that you do not ignore these symptoms and check with your physician immediately.
Also remember while evaluating the Tests, do not refer to Internet and form your conclusions.
Some times the information may be inaccurate and the fact that the symptoms may be indicative of some other diseases as well.
It is also that the first ten results of Google Search need not contain the correct information.
Story:
1. Breast Changes
“If you feel a lump, you shouldn’t ignore it, even if your mammogram is normal,” says Carolyn Runowicz, MD, a breast cancer survivor and professor of obstetrics and gynecology at Florida International University’s Herbert Wertheim College of Medicine and past president of the American Cancer Society. If your nipple develops scaliness or flaking, that could indicate Paget’s disease of the nipple, which is associated with an underlying cancer in about 95% of cases. Any milky or bloody nipple discharge should also be checked out.
Once you hit menopause (defined as 12 months without a period), any postmenopausal bleeding is a warning sign, says Runowicz. “Any bleeding, staining, little drops on your underwear, or big clots are abnormal and should be immediately investigated,” she says. Such bleeding could indicate something as benign as an endometrial polyp or something more serious like endometrial or cervical cancer.
Bleeding that is uncharacteristic for you — spotting outside of your normal menstrual cycle or heavier periods — should be looked into, says Karlan. Around menopause, abnormal bleeding is often attributed to hormonal shifts, though more serious problems could be the cause, which is why all abnormal vaginal bleeding should be evaluated. Expect to receive a transvaginal sonogram and perhaps a biopsy.
3. Rectal Bleeding
Colon cancer is the third most common cancer in women. One of the hallmarks is rectal bleeding, which many people attribute to hemorrhoids, the most common cause. “But it’s not always that,” says Karlan. Red or dark blood in your stool warrants a visit to your doctor, she says.
Your doctor will likely do a rectal exam and order a colonoscopy if you’re 50 or older and perhaps even if you’re younger.
4. Discharge
A foul or smelly vaginal discharge could be a sign of cervical cancer, says Runowicz. The discharge may contain blood and may occur between periods or after menopause. It’s best not to self-treat a discharge with over-the-counter medications, she advises.
An exam is necessary to determine if the discharge is due to an infection or something more serious.
5. Bloating
“Ovarian cancer is the No. 1 killer of all the reproductive-organ cancers,” says Karlan. “For years it’s been known by the misnomer of the silent killer, and we really need to put that aside. Ovarian cancer clearly has symptoms.” The four most frequent are bloating; feeling that you’re getting full earlier than you typically would when eating; changing bowel or bladder habits, such as urinating more frequently; and low back or pelvic pain.
It’s not unusual to have one or two of these symptoms occasionally, particularly after a big meal. But pay attention if you have two or more symptoms occurring daily for more than two weeks. “If they’re persistent and progressive,” says Karlan, “call your physician.”
Expect a pelvic exam, transvaginal sonogram, and perhaps a CA-125 blood test to check for cancerous cells.
6. Unexplained Weight Gain or Loss
“If you suddenly put on 5 pounds, I wouldn’t worry,” says Runowicz. But gaining excess weight month to month — especially if you usually maintain a normal weight and watch what you eat — can be due to an accumulation of fluid in the belly related to ovarian cancer and warrants seeing your doctor, she says.
Unexplained weight loss of 10 pounds or more “may be the first sign of cancer,” according to the American Cancer Society, and is most often associated with pancreatic, stomach, esophagus, or lung cancer.
But weight loss in women is often caused by a hyperactive thyroid, says Runowicz. Expect your doctor to order a thyroid test first to check for this common disease.
Any persistent cough — one that lasts more than two or three weeks and is not due to an allergy or upper respiratory infection or one that produces blood in the sputum — needs to be checked by your doctor. If your cough may be caused by smoking or being exposed to second-hand smoke, get it checked out. “Smoking is the number one cancer killer of women,” says Karlan. Yet you don’t have to be a smoker to be at risk; the majority of lung cancers that occur in nonsmokers also occur in women. Expect your doctor to order a chest X-ray and perhaps a CT scan.
“If you feel hard lymph nodes in your neck or under your arm, you should be seen by a doctor,” advises Runowicz. Swollen, firm lymph nodes are often the result of an infection. However, lymphoma or lung, breast, head, or neck cancer that has spread can also show up as an enlarged lymph node. Expect a physical exam and possibly a biopsy.
9. Fatigue
Although fatigue can be hard to quantify, the American Cancer Society defines it as “extreme tiredness that does not get better with rest.” If you’re persistently fatigued, see your doctor. Leukemia, colon, or stomach cancer — which can cause blood loss — can result in fatigue.
“Fatigue can be a serious problem and it’s easy to ignore,” says Runowicz, who notes your doctor will most likely do a physical exam and order blood tests to evaluate your thyroid and rule out a thyroid condition.
10. Skin Changes
Keep an eye on any changes you notice on your skin all over your body, and call your doctor right away if anything concerns you.
Sores in the mouth that don’t heal — especially if you smoke or drink alcohol — may be a sign of oral cancer and should be examined by your physician.
In particular, note any sores or irritated skin in the vaginal area. “A nonhealing vulvar lesion could be a sign of vulvar cancer,” says Runowicz. Changes in moles or pigmented lesions on the vulva can also signify cancer. “Vulvar melanoma can frequently be overlooked and can have a very aggressive course,” says Karlan. A simple biopsy can be done in your doctor’s office if necessary.
Micrograph of a low malignant potential mucinous ovarian tumour. H&E stain.
Please read this & share with your families..
An Eye Opener on Ovarian Cancer-This has been sent to me by my friend Sri.Srinivasan, renowned cardiologist.I thought I should share with you all.
I hope you all take the time to read this and pass it on to all you can. Send this to the women in your life that you care about.
A few years ago, Gilda Radner died of ovarian cancer. Her symptoms were inconclusive, and she was treated for everything under the sun until it was too late. This blood test finally identified her illness but alas, too late. She wrote a book to heighten awareness. Gene Wilder is her widower.
KATHY’S STORY: this is the story of Kathy West
As all of you know, I have Primary Peritoneal Cancer. This cancer has only recently been identified as its OWN type of cancer, but it is essentially Ovarian Cancer.
Both types of cancer are diagnosed in the same way, with the “tumor marker” CA-125 BLOOD TEST, and they are treated in the same way – surgery to remove the primary tumor and then chemotherapy with Taxol and Carboplatin.
Having gone through this ordeal, I want to save others from the same fate. That is why I am sending this message to you and hope you will print it and give it or send it via E-mail to everybody you know.
One thing I have learned is that each of us must take TOTAL responsibility for our own health care. I thought I had done that because I always had an annual physical and PAP smear, did a monthly Self-Breast Exam, went to the dentist at least twice a year, etc. I even insisted on a sigmoidoscopy and a bone density test last year. When I had a total hysterectomy in 1993, I thought that I did not have to worry about getting any of the female reproductive organ cancers.
LITTLE DID I KNOW. I don’t have ovaries (and they were HEALTHY when they were removed), but I have what is essentially ovarian cancer. Strange, isn’t it?
These are just SOME of the things our Doctors never tell us: ONE out of every 55 women will get OVARIAN or PRIMARY PERITONEAL CANCER.
The “CLASSIC” symptoms are an ABDOMEN that rather SUDDENLY ENLARGES and CONSTIPATION and/or DIARRHEA.
I had these classic symptoms and went to the doctor. Because these symptoms seemed to be “abdominal”, I went to a gastroenterologist. He ran tests that were designed to determine whether there was a bacteria infection; these tests were negative, and I was diagnosed with “Irritable Bowel Syndrome“. I guess I would have accepted this diagnosis had it not been for my enlarged abdomen. I swear to you, it looked like I was 4-5 months pregnant! I therefore insisted on more tests.
They took an X-ray of my abdomen; it was negative. I was again assured that I had Irritable Bowel Syndrome and was encouraged to go on my scheduled month-long trip to Europe. I couldn’t wear any of my slacks or shorts because I couldn’t get them buttoned, and I KNEW something was radically wrong. I INSISTED on more tests, and they reluctantly) scheduled me for a CT-Scan (just to shut me up, I think).
This is what I mean by “taking charge of our own health care.”
The CT-Scan showed a lot of fluid in my abdomen (NOT normal). Needless to say, I had to cancel my trip and have FIVE POUNDS of fluid drawn off at the hospital (not a pleasant experience I assure you), but NOTHING compared to what was ahead of me.
Tests revealed cancer cells in the fluid. Finally, finally, finally, the doctor ran a CA-125 blood test, and I was properly diagnosed.
I HAD THE CLASSIC SYMPTOMS FOR OVARIAN CANCER, AND YET THIS SIMPLE CA-125 BLOOD TEST HAD NEVER BEEN RUN ON ME, not as part of my annual physical exam and not when I was symptomatic. This is an inexpensive and simple blood test!
PLEASE, PLEASE TELL ALL YOUR FEMALE FRIENDS AND RELATIVES TO INSIST ON A CA-125 BLOOD TEST EVERY YEAR AS PART OF THEIR ANNUAL PHYSICAL EXAMS.
Be forewarned that their doctors might try to talk them out of it, saying, “IT ISN’T NECESSARY.” Believe me, had I known then what I know now, we would have caught my cancer much earlier (before it was a stage 3 cancer). Insist on the CA-125 BLOOD TEST; DO NOT take “NO” for an answer!
The normal range for a CA-125 BLOOD TEST is between zero and 35. MINE WAS 754. (That’s right, 754!). If the number is slightly above 35, you can have another done in three or six months and keep a close eye on it, just as women do when they have fibroid tumors or when men have a slightly elevated PSA test (Prostatic Specific Antigens) that helps diagnose prostate cancer.
Having the CA-125 test done annually can alert you early, and that’s the goal in diagnosing any type of cancer – catching it early..
Do you know 55 women? If so, at least one of them will have this VERY AGGRESSIVE cancer. Please, go to your doctor and insist on a CA-125 test and have one EVERY YEAR for the rest of your life..
And forward this message to every woman you know, and tell all of your female family members and friends. Though the median age for this cancer is 56, (and, guess what, I’m exactly 56), women as young as 22 have it. Age is no factor.
A NOTE FROM AN RN:
Well, after reading this, I made some calls. I found that the CA-125 test is an ovarian screening test equivalent to a man’s PSA test prostate screen (which my husband’s doctor automatically gives him in his physical each year and insurance pays for it). I called the general practitioner’s office about having the test done. The nurse had never heard of it. She told me that she doubted that insurance would pay for it. So I called Prudential Insurance Co, and got the same response. Never heard of it – it won’t be covered.
I explained that it was the same as the PSA test they had paid for my husband for years. After conferring with whomever they confer with, she told me that the CA-125 would be covered.
It is $75 in a GP’s office and $125 at the GYN’s. This is a screening test that should be required just like a PAP smear
(a PAP smear cannot detect problems with your ovaries).
And you must insist that your insurance company pay for it.
Gene Wilder and Pierce Brosnan (his wife had it, too) are lobbying for women’s health issues, saying that this test
should be required in our physicals, just like the PAP and the mammogram. PLEASE TAKE A MOMENT TO SEND THIS OUT TO ALL THOSE YOU CAN. BE IT MALE OR FEMALE, IT SHOULD NOT MATTER, AS THEY CAN FORWARD IT ALSO TO THOSE LOVED ONES THEY KNOW.
IF YOU HAVE A PROBLEM WITH FORWARDING SOMETHING
AS IMPORTANT AS THIS, HERE’S A LITTLE HINT THAT MAY ASSIST YOU WITH YOUR DECISION ~ JUST PRETEND THAT THIS IS A JOKE, WHICH IT CERTAINLY IS NOT, AND SEND IT OUT TO ALL THE FOLKS YOU WOULD IF IT WAS.
Ovarian cancer can be deadly, is often caught in an advanced stage, and strikes many women every year.
“Ovarian cancer is the second most common gynecologic malignancy — approximately 21,650 new cases each year, with an estimated 15,500 deaths each year,” says William Edward Richards, MD, associate professor and director of women’s cancer at the University of Cincinnati’s Barrett Cancer Center. “It’s the fifth most common cause of cancer death and the most common cause of gynecologic cancer death.”
With these frightening statistics, more women should be asking questions about ovarian cancer.
Ovarian Cancer Awareness: Who’s Working on It?
“Most women are not aware of the threat of ovarian cancer,” says Robin Cohen, co-founder of the Sandy Rollman Ovarian Cancer Foundation, which is an umbrella organization of the Ovarian Cancer National Alliance. “Many of the umbrella organizations are working at the local level to educate both women and physicians about the risks and symptoms of ovarian cancer,” says Cohen.
Most (>90%) ovarian cancers are classified as “epithelial” and were believed to arise from the surface (epithelium) of the ovary.[1][2] However, recent evidence suggests that the Fallopian tube could also be the source of some ovarian cancers.[3] Since the ovaries and tubes are closely related to each other, it is hypothesized that these cells can mimic ovarian cancer.[4] Other types arise from the egg cells (germ cell tumor) or supporting cells (sex cord/stromal).
In 2004, in the United States, 25,580 new cases were diagnosed and 16,090 women died of ovarian cancer. The risk increases with age and decreases with pregnancy. Lifetime risk is about 1.6%, but women with affected first-degree relatives have a 5% risk. Women with a mutated BRCA1 or BRCA2 gene carry a risk between 25% and 60% depending on the specific mutation.[5] Ovarian cancer is the fifth leading cause of death from cancer in women and the leading cause of death from gynecological cancer.[6]
The signs and symptoms of ovarian cancer are most of the times absent, but when they exist they are nonspecific. In most cases, the symptoms persist for several months until the patient is diagnosed.
A prospective case-control study of 1,709 women visiting primary care clinics found that the combination of bloating, increased abdominal size, and urinary symptoms was found in 43% of those with ovarian cancer but in only 8% of those presenting to primary care clinics.[18]
Accuracy of symptoms
Two case-control studies, both subject to results being inflated by spectrum bias, have been reported. The first found that women with ovarian cancer had symptoms of increased abdominal size, bloating, urge to pass urine and pelvic pain.[12] The smaller, second study found that women with ovarian cancer had pelvic/abdominal pain, increased abdominal size/bloating, and difficulty eating/feeling full.[19] The latter study created a symptom index that was considered positive if any of the six (6) symptoms “occurred >12 times per month but were present for <1 year”. For early-stage disease, they reported a 57% sensitivity and 87% to 90% specificity.
Consensus statement
In 2007, the Gynecologic Cancer Foundation, Society of Gynecologic Oncologists and American Cancer Society originated the following consensus statement regarding the symptoms of ovarian cancer.[20]
Ovarian cancer is called a “silent killer” because symptoms were not thought to develop until the disease had advanced and the chance of cure or remission poor. However, the following symptoms are much more likely to occur in women with ovarian cancer than women in the general population. These symptoms include:
Bloating
Pelvic or abdominal pain
Pain in the back or legs
Diarrhea, gas, nausea, constipation, indigestion
Difficulty eating or feeling full quickly
Urinary symptoms (urgency or frequency)
Pain during sex
Abnormal vaginal bleeding
Trouble breathing
Women with ovarian cancer report that symptoms are persistent and represent a change from normal for their bodies. The frequency and/or number of such symptoms are key factors in the diagnosis of ovarian cancer. Several studies show that even early stage ovarian cancer can produce these symptoms. Women who have these symptoms almost daily for more than a few weeks should see their doctor, preferably a gynecologist. Prompt medical evaluation may lead to detection at the earliest possible stage of the disease. Early stage diagnosis is associated with an improved prognosis.
Several other symptoms have been commonly reported by women with ovarian cancer. These symptoms include fatigue, indigestion, back pain, pain with intercourse, constipation and menstrual irregularities. However, these other symptoms are not as useful in identifying ovarian cancer because they are also found in equal frequency in women in the general population who do not have ovarian cancer.[citation needed]
Cause
The exact cause is usually unknown. The risk of developing ovarian cancer appears to be affected by several factors. The more children a woman has, the lower her risk of ovarian cancer. Early age at first pregnancy, older age of final pregnancy and the use of low dose hormonal contraception have also been shown to have a protective effect. Ovarian cancer is reduced in women after tubal ligation.[citation needed]
Hormones
The relationship between use of oral contraceptives and ovarian cancer was shown in a summary of results of 45 case-control and prospective studies. Cumulatively these studies show a protective effect for ovarian cancers. Women who used oral contraceptives for 10 years had about a 60% reduction in risk of ovarian cancer. (risk ratio .42 with statistical significant confidence intervals given the large study size, not unexpected). This means that if 250 women took oral contraceptives for 10 years, 1 ovarian cancer would be prevented. This is by far the largest epidemiological study to date on this subject (45 studies, over 20,000 women with ovarian cancer and about 80,000 controls).[21]
The link to the use of fertility medication, such as Clomiphene citrate, has been controversial. An analysis in 1991 raised the possibility that use of drugs may increase the risk of ovarian cancer. Several cohort studies and case-control studies have been conducted since then without demonstrating conclusive evidence for such a link.[22] It will remain a complex topic to study as the infertile population differs in parityfrom the “normal” population.
Genetics
There is good evidence that in some women genetic factors are important. Carriers of certain mutations of the BRCA1 or the BRCA2gene are notably at risk. The BRCA1 and BRCA2 genes account for 5%-13% of ovarian cancers[23] and certain populations (e.g. Ashkenazi Jewishwomen) are at a higher risk of both breast cancer and ovarian cancer, often at an earlier age than the general population.[citation needed]Patients with a personal history of breast cancer or a family history of breast and/or ovarian cancer, especially if diagnosed at a young age, may have an elevated risk.
A pooled analysis of ten (10) prospective cohort studies conducted in a number of countries and including 529,638 women found that neither total alcohol consumption nor alcohol from drinking beer, wine or spirits was associated with ovarian cancer risk.”[24] The results of a case-control study in the region of Milan, Italy, “suggests that relatively elevated alcohol intake (of the order of 40 g per day or more) may cause a modest increase of epithelial ovarian cancer risk”.[25] “Associations were also found between alcohol consumption and cancers of the ovary and prostate, but only for 50 g and 100 g a day.”[26] “Statistically significant increases in risk also existed for cancers of the stomach, colon, rectum, liver, female breast, and ovaries.”[27]
Other
A Swedish study, which followed more than 61,000 women for 13 years, has found a significant link between milk consumption and ovarian cancer. According to the BBC, “[Researchers] found that milk had the strongest link with ovarian cancer—those women who drank two or more glasses a day were at double the risk of those who did not consume it at all, or only in small amounts.”[28] Recent studies have shown that women in sunnier countries have a lower rate of ovarian cancer, which may have some kind of connection with exposure to Vitamin D.[29]
Other factors that have been investigated, such as talc use,[30]asbestos exposure, high dietary fat content, and childhood mumps infection, are controversial[citation needed] and have not been definitively proven; moreover, such risk factors may in some cases be more likely to be correlated with cancer in individuals with specific genetic makeups.[31]
Screening
Routine screening of the general population is not recommended by any professional society. This includes the U.S. Preventive Services Task Force, the American Cancer Society, the American College of Obstetricians and Gynecologists, and the National Comprehensive Cancer Network.[36]
No trial has shown improved survival for women undergoing screening.[36]
Screening tests include the CA-125 marker, transvaginal ultrasound, and possibly a proprietary marker test combination such as OvaSure (LabCorp). A definitive diagnosis implies strong consideration of surgical excision of the ovaries and fallopian tubes. But all lab tests have a statistical false positive rate (“false alarm” rate). So a positive screening test must not represent a demand that the patient be followed up by surgery.[36]
The purpose of screening is to discover ovarian cancer in early stages, when it is more curable, on the hypothesis that early-stage cancer develops into later-stage cancer. However, it is not known whether early stage ovarian cancer evolves to later stage cancer, or whether stage III (peritoneal cavity involvement) arises as a diffuse process.[36]
The goal of ovarian cancer screening is to detect ovarian cancer at stage I.[37] Several large studies are ongoing, but none have recommended screening.[38] In 2009, however, Menon et al. reported from the UKCTOCS that utilizing mutimodal screening, in essence first performing annual CA-125 testing, followed by ultrasound imaging on the secondary level, the positive predictive value was 35.1% for primary invasive epithelial ovarian and tubal carcinoma, making such screening feasible.[39] However, it remains to be seen if such screening is effective to reduce mortality.
Management
Surgical treatment may be sufficient for malignant tumors that are well-differentiated and confined to the ovary. Addition of chemotherapy may be required for more aggressive tumors that are confined to the ovary. For patients with advanced disease a combination of surgical reduction with a combination chemotherapy regimen is standard. Borderline tumors, even following spread outside of the ovary, are managed well with surgery, and chemotherapy is not seen as useful.
Surgery is the preferred treatment and is frequently necessary to obtain a tissue specimen for differential diagnosis via its histology. Surgery performed by a specialist in gynecologic oncology usually results in an improved result.[40] Improved survival is attributed to more accurate staging of the disease and a higher rate of aggressive surgical excision of tumor in the abdomen by gynecologic oncologists as opposed to general gynecologists and general surgeons.
The type of surgery depends upon how widespread the cancer is when diagnosed (the cancer stage), as well as the presumed type and grade of cancer. The surgeon may remove one (unilateral oophorectomy) or both ovaries (bilateral oophorectomy), the fallopian tubes (salpingectomy), and the uterus (hysterectomy). For some very early tumors (stage 1, low grade or low-risk disease), only the involved ovary and fallopian tube will be removed (called a “unilateral salpingo-oophorectomy,” USO), especially in young females who wish to preserve their fertility.
In advanced malignancy, where complete resection is not feasible, as much tumor as possible is removed (debulking surgery). In cases where this type of surgery is successful (i.e. < 1 cm in diameter of tumor is left behind [“optimal debulking”]), the prognosis is improved compared to patients where large tumor masses (> 1 cm in diameter) are left behind. Minimally invasive surgical techniques may facilitate the safe removal of very large (greater than 10 cm) tumors with fewer complications of surgery.[41]
Chemotherapy has been a general standard of care for ovarian cancer for decades, although with highly variable protocols.[42] Chemotherapy is used after surgery to treat any residual disease, if appropriate. This depends on the histology of the tumor; some kinds of tumor (particularly teratoma) are not sensitive to chemotherapy. In some cases, there may be reason to perform chemotherapy first, followed by surgery.
For patients with stage IIIC epithelial ovarian adenocarcinomas who have undergone successful optimal debulking, a recent clinical trial demonstrated that median survival time is significantly longer for patient receiving intraperitoneal (IP) chemotherapy.[43] Patients in this clinical trial reported less compliance with IP chemotherapy and fewer than half of the patients received all six cycles of IP chemotherapy. Despite this high “drop-out” rate, the group as a whole (including the patients that didn’t complete IP chemotherapy treatment) survived longer on average than patients who received intravenous chemotherapy alone.
Some specialists believe the toxicities and other complications of IP chemotherapy will be unnecessary with improved IV chemotherapy drugs currently being developed.
Although IP chemotherapy has been recommended as a standard of care for the first-line treatment of ovarian cancer, the basis for this recommendation has been challenged.[44]
Radiation therapy is not effective for advanced stages because when vital organs are in the radiation field, a high dose cannot be safely delivered. Radiation therapy is then commonly avoided in such stages as the vital organs may not be able to withstand the problems associated with these ovarian cancer treatments.[45]
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